Maldor the Malevolent: He is a ghostly warlock from the Dark Ages who is a master of the black arts. Maldor is very ungenerous and impatient as he showed when he searched for the wand and as he looked for Scooby-Doo. His most powerful spells include creating a near irreversible sleep and causing himself to grow to gigantic sizes.
Played By: Peter Cullen
Queen Morbida: She is a vampire-like queen who is the commander of an army of monsters. Queen Morbida is obviously the leader of the assembled monsters. She is bold, arrogant and cruel, but is also a touch oblivious... for instance, she didn't even think to check her bedchamber for the stolen Chest of Demons, even though it was in Befuddle Hall and thus a possible location.
Played By: Linda Gary
Reflector Spectre: He is a mirror demon who can trap people in his mirror. While contained in his mirror, he can appear not at all, or his face can appear, or he can make the entire mirror shine with ghostly energy. While in the Mirror Dimension, he controls every aspect of the environment -- the floors, gravity, even the sizes of things or people he sees.
Played By: Michael Rye
Zomba: She is a zombie demon who can transport people into movies and TV shows. She's addicted to releasing the Demon Chest ghosts (her motive for this end is never clear), she loves eating like Scooby and Shaggy comparing that she ate popcorn, and often uses her frightful appearance to intimidate—but she has a tendency to believe whatever she's told, making her relatively easy to trick.
Played By: Susan Blu
Captain Ferguson: He is a ghostly sea captain and his crew who haunted the Bermuda Triangle on his ghost ship. He is easily irritated, but is able to hide it well when in human form. He is also usually polite when he is in human form, as well as when he was disguised as a travel agent. However, he was demanding and quite rude when in ghost form.
Played By: Robert Ridgely
Nekara: She is an enchantress who can drain other magic users of their magic with her Trance of Love. Nekara prefers to use minions to carry out her plans, employing force only when her victim is under her control or the time is dire. She's arguably the only truly paranormal villain willingly pursued by the gang without rallying their bravery or being bribed to do so.
Played By: Adrienne Barbeau
Marcella: She is a witch who manipulated three bumbling witches called the Brewski Sisters into freeing her. She appears to them as mist. However, she can also take on a more tangible form. In the latter form, she wears a red and purple outfit, has gray and black hair, and a medallion around her neck. She's cold-blooded and wicked enough to capture Vincent Van Ghoul singlehandedly.
Played By: B.J. Ward
Time Slime: He is a demon who can control the flow of time. Time Slime is as ambitious as he is tyrannical. His objective of world conquest seems only for the sake of defiling the world and having everyone in it under his rule. He is abrasive to his subordinates. He is very rude and has a penchant for designing elaborate demises for his enemies, which is his undoing -- when Scooby, infused with an uncharacteristic bout of courage, attacked and eliminated his trap, causing it to backfire.
Played By: Rodger Bumpass
Demondo: He is a demon who can imprison people in books and comic strips. He makes a slurping sound when he speaks. He is also known as being discourteous, emotionless, menacing, obnoxious, negative, diligent, obstinate, devilish, evil, mischievous, obsessive, nasty, determined and outlandish.
Played By: Peter Renaday
Rankor: is a vampire demon who sought to join S.A.P.S. by having Vincent Van Ghoul look into the Eye of Eternity which slowly turned him to stone. He's mercilessly determined to both eliminate the demon chest and one day joining S.A.P.S. He'll go to great lengths to succeed at both of them at the same time. He deeply hates sunlight since he's a vampire.
Played By: Hamilton Camp
Professor Phantazmo: He is the ringmaster of the Circus of Horrors which is staffed by demons and monsters. In contrast to the other 13 Ghosts, he is not menacing or enigmatic on first appearance. In fact, he's good-humored and full of showmanship, like a typical ringmaster. He shows a dark and vicious underlying menace on occasion, suggesting that his affable demeanor is just a front to put mortals off guard.
Played By: Alan Oppenheimer
Simbooloo: He is a horned lion demon with goat-like hooves who posed as a medium named Tallulah. He is very ferocious, arrogant, ingenious and determined to release his fellow demons from the Chest of Demons and to gain all the power in the universe. He'll stop at nothing to achieve that goal. Simbooloo was so menacing and intimidating that both Bogel and Weerd groveled on their knees and kissed his hooves.
Played By: Frank Welker
Asmodeus: He is Asamad Van Ghoul, the final ghost, and Vincent's ancestor who went mad with power and had to be sealed within the Chest of Demons. It was in the chest where he supposedly became a demon. He is a tall, dark red-purple humanoid with with a pair of wings on its back. He seeks to release all the ghosts once more and become their ruler.
Played By: Kevin Conroy