The real reason the Biophage didn't adapt is because it was debatably sapient, even if it was very good at doing what it was probably created to do. I remember it's attempts to fake communications were very shoddy beyond a basic level. It certainly wasn't smart enough to deliberately genetically engineer new strains of itself to get around the vaccine, and luckily it did not have the capacity to do so naturally. The Singers created themselves, and they run a very scientifically advanced polity, so it's fair to say they can meet us technobabble to technobabble.
Mentats honestly aren't the finest example because, well, there's actually already a structure in Licori society meant to contain Mentats. We know this because they would have certainly blown up Morshadd before we met them if that wasn't the case. This structure was failing at the time only because of what amounted to political nonsense, once the war ended the Licori did what we wanted them to more or less on their own.
There is no Singer containment bureau, the Singers run all the bureus, the only people Singers listen to are other Singers. And when a Singer disagrees with the rest and is caught, the things we know are done to that Singer are not what we'd call Federation approved anyway.
The Singers are also a fair bit more coordinated and used to working together than Mentats, who're maniacal scientists with all that entails.
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