Just as a comment about relative threats, Drycha is dangerous, but she's by far the most dangerous when buffed and with the initiative.
In terms of danger when Mathilde is the one attacking, I'd expect both the Treemen and the Manticore to be harder targets that are more likely to kill her.
In terms of danger when Mathilde is the one attacking, I'd expect both the Treemen and the Manticore to be harder targets that are more likely to kill her.