:/
No it doesn't. That was a "character creation only" thing: you could only pick so many unusual options. It wasn't a mechanical penalty of any kind.
It's based on an existing setting in which far more women than men get powers (well, without mutating or dying) for some reason. Presumably the author wanted to try for some sort of social commentary or something. But once the dude in question has his superpowers, he doesn't seem weaker than anyone else. A dude called Zeus rules most of the planet in the original serial, and the strongest person in the world is an African-American woman that everybody hates and fears but who's still living her best life anyway.
Living her best life as an evil piece of shit, but living her best life nonetheless
Worse: there are whole PrCs like that!
Ever heard of Durthan? It's an amazing Tier 1 PrC (for Sha'ir, or Theurges) with the absurdly good "Place Magic" ability (Acorn of Far Travel, yeah!), that allows you to cast any spell known without preparation.
It's also unavailable to men.
+1
The Quest. We play an Ultrahuman (superpowered) fighter in the service of the Ultra-supremacist Regime, who is secretly a member of the Ultra-hating group Kill Every Monster. Her healing power means that she's old enough to remember the fall of civilization at the hands of Ultra warlords, and so she hates them all.
The Web Serial the quest's setting is based on. Reading it shouldn't be necessary to follow the quest (the quest if just starting, and the author is paying attention to exposition) but the serial was pretty good so I would suggest reading it.
To summarize: civilisation is dying, but not mankind. Superpowered humans known as "Ultras" roam, and everything is a chaotic shitpile. No controlling Lawful Evil Dystopia here - just feuding warlords who act like they're gods all over Pantheon territory, one asshole ruling all of America and bullying the world with her insane personal power, and one last police state in Europe fighting back against the Ultra hordes and their human ("dagger") groupies/slaves/followers.
The main characters are enforcers working for the American dictator, even though they all hate and fear her. Trouble is, they each have their own traitorous ambitions and then [PLOT HAPPENS].
Great twists, interesting worldbuilding, and a the writing isn't bad either. Most of its readers are on another website, but it's crossposted here very week.