I would bring up the fact that the QM has specifically stated that ignoring mainline quests are a very bad idea. Better partially complete than outright ignoring. The only main quest that Silently said we could potentially ignore without bad consequence is the exploration one.SW has a plan for this and it's a multi-part quest, so part 2 might just be "Go get Cranial to help out" but probably not, it'll probably be something else.
I really was tempted, but starting Bone of the Father and then jumping to another quest part way seemed like a bad idea. Best to finish the quest we started before taking a new one or we end up with 4 quests all at Step 2.
Also. We can see what comes of Bones part 2 then see if we want to immediately follow up on it. Plus, while it's a good bonus to not have Nazis in the local area I want the freaking Protectorate and PRT to actually do their jobs against the villains. We don't have to personally put out all the fires. If we take down one or two of the Nazi capes I call that a win and the questline can lay there for a week.
As for Sinners. The most important part is killing off the Simurgh cultists. Especially the leader of the Mathers branch. After that the Protectorate should be able to actually do their fucking job for once since the blanket protection from Thinker and Precogs will be lifted from the Fallen.
And if Alexandria is actually competent at all she'd damn well have Protectorate ready to take advantage of the Fallen being in disarray once we destroy the Mathers branch.
Remember that it's not just Taylor and co. that have agency. Others do too.
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