Yes, ah, cruise missiles are legitimately threatening for a variety of reasons.
The biggest way to mitigate that threat is simply not to get hit or be in proximity to one going off to begin with, which a high level full caster can definitely manage, but putting yourself in position to get hit by one in the first place, to what, to prove a point?
This is just asking for a low yield nuclear weapon to go off, and even if it doesn't kill you, do you want to be responsible for bringing on that kind of heat? Congratulations, you're the asshole who thought getting into a dick waving contest with a modern military-industrial complex who, for the sake of the narrative, apparently can't countenance being made a fool of by an overgrown fire-breathing lizard was a good idea, and now everyone recognizes you as the preening reptile who caused fallout to wash over Little Jimmy and Susie's after-school function.