Bless! Glad we were truly able to help Sakura, especially when things were this dire. That's what I wanted the most out of that last choice. Also,
"She'll be fine, Shirou," Medea says, a deep frown on her face as she continues to look over Sakura. "This is… personal."
Really glad for this. Caster and Sakura are women who can relate to each other p well (especially after some scenes I've seen from Hollow Ataraxia). It's really nice to see Caster's reaction to a woman in a similar situation be "I need to save her". It's a good contrast to her reaction to girls like Saber (a pure girl she needs to corrupt). Obviously, some Shirou influence showing through, but I'm always glad to see this kinder side to her.
Now it seems as if our 2 witches are going to be able to interrogate an Archer. Hopefully this can help them get an even better understanding of our protagonist (although Caster needs that help more than Circe). Also, this Leysritt bit keeps delivering.
As for the three options (although i disagree that his parents survived):
[X] ["Because my life is worth nothing."]
All have a hint of Shirou at his most pessimistic, but I feel like the latter two go a bit too far. 2nd with the "Nobody helps", 3rd with the "I will kill anyone who threatens them". Both thoughts that Shirou is capable of, especially the 3rd one for this particular quest, but they do not feel core to his identity.
The first though, that feels really like the crux of Shirou's issues. Stuff he subconsciously believes that had to be addressed in each route of the VN. I think with how Shirou just helped Sakura, it's time for someone to hear his problems from the gut. Also, we should really throw Ayako a bone. Can't think of a better way of treating her like a serious heroine than having
this Shirou talk.