I definitely think that we should think a bit more narratively than mechanically when it comes to our DNA samples.
For instance, Nox - his DNA has a lot of tags and that's a bit intimidating, but his main thing is emotional vampirism. That means he might be a great mix with, for instance, Eastwood and Chatroom. If we mix those together you probably have a really strong Empath powerset - someone who can sense people's emotion, absorb them, and maybe mix them together for esoteric effects.
It's probably not what we'd want for Yara, because it sounds like people want the entire psychic package, whatever that looks like.
But, similarly... I'm a bit hesitant about the Witch Master build because Feth Faida's main thing is making a fog with esoteric effects - the mental effects are secondary to the fog so even if it contributes to Mental Manipulation, the end result might look odd.