That's complicated.
It was revealed that humans were supposed to evolve into kryptonian like beings, but the white martians mucked with human evolution to instead give the metagene.
Of course humanity had already existed for about 180,000 years at this point, so perhaps what was intended was that the proto-metagene would activate when someone was in danger or whatever and everyone would get kryptonian style powers despite their origins. Hit by lightning? Flying brick. Hit by a bus? Flying brick. Bathed by eldritch radiation because a lovecraftian deity came to borrow some sugar? Flying brick.
Later, the people of Atlantis were altered by all the magic energy floating around, creating homo magi. Despite being named like they are a different species, there might not actually be a single genetic difference between magi and muggles, it might be more along a difference in souls like how Zoat made the difference between new gods and humans.
In
Zenobrood, a more obscure dc work, it was revealed that the alien Vimanians had their organic crystal androids mate with pre-homo sapiens hominids intending to create an entire planet of superslaves.
In Swamp Thing, the title character met the
Cancer God, who claims that he's been manipulating evolution on Earth since life first spawned on the planet.
With the previous talk about Alpha Centauri I'm now picturing Grayven getting the "merge with planet ending," just in a more of the Thing way.
Then there's that bit about humanity being the New God's successors, which I don't really know much about, but the Super Young Team is supposed to be the new "incarnation" of the forever people, at least two humans apparently knew the anti-life formula instinctively, also the New Gods empowered a
neanderthal, who has who knows how many descendants in the modern day, including the superheroine Bulleteer.
Likewise a Controller gave a prehistoric man superpowers to defend Earth against Mageddon, although whether he had any children or if what was done to him was in any way inheritable wasn't discussed.
Speaking of human evolution, there's an interesting little tidbit from the Human Race comic- an alien came to Earth with a virus capable of entirely rewriting DNA, such that even those who survive don't qualify as human anymore. Paracelsus, a former member of that secret society, apparently feels that humans are obsolete and seeks to hasten the replacement of humanity with xenovirus survivors. I could just imagine Wally mentioning "So he's OL, but EVIL."
Edit- And in one origin of Atlantis, Atlantis was founded by the aliens who hunted the dinosaurs to extinction, the Hunter/Gatherers, who apparently mated with humans and possibly other species as well.