DIO, in the course of enjoying freedom after 100 years under the sea, managed to father four kids, all of whom he either forgot about, didn't care about, or didn't even know existed.
There is the aforementioned Giorno, protagonist of Part 5, wielder of the stand Gold Experience, later upgraded to Gold Experience Requiem. No explanation needed.
But there are three others, all of whom show up as villians in Part 6 after Enrico Pucci tracked them down.
Donatello Versus, who awakened to a Stand called Under World which literally can cause history to repeat by causing specific events to repeat between specified individuals. Events can include ones where one participant dies, and any participant in that event who did not die is in fact precluded from dying for the duration.
Rikiel, who has the stand Sky High, which controls countless tiny invisible creatures known as 'Rods', thought to be invisible tiny flying creatures that move at speeds invisible to the naked eye only seen when photographed in freefall. In reality, such a thing is an optical illusion, but this Stand uses actual creatures, and can direct them to attack his targets. Normally, the attack isn't particularly dangerous, unless heavily focused on a lethal point like the back of the neck. The advantage they have is that they are generally invisible, attack in great numbers, and can be controlled at great ranges.
Ungalo, who has the stand Bohemian Rhapsody, which has infinite range, no physical presence, but has the ability to bring fictional characters depicted in pictures to life, and should anyone encounter a character brought to life that they like, they will be forced into that character's role and share that character's fate in his story. The dude pulls the craziest shit out of all of them, bringing characters to life en masse across the world, and we get crazy shit happening like Kenshiro and Raoh from Fist of the North Star dueling in Tokyo! Granted, it was only mentioned in a new report as something that has happened, Jojo can't quite flaunt copyright that flagrantly despite how it loves to take musical names for everything.