At this point, its basically a good bit of distance beyond the star system. Not close to a lightyear or anything, but still pretty far.
Hi! Funny you should bring this up, Flood in the Halo games are really fucking good at taking hits from kinetic rounds like what humanity uses. As in, they're basically immune to one of the most powerful guns in the game (the sniper rifle). They have a rougher time with plasma and explosive weapons.
Flood do have vital organs, though they don't need nearly as many as ordinary lifeforms. If you deal enough damage, particularly with plasma weapons, they'll basically 'die' though they can be resurrected/repaired by infection forms sometimes. That's one of the reasons why its important in the games to destroy the bodies after killing them. As in, one of those pods will hop in that combat form that you just barely managed to kill earlier and now its back up and slapping you around again. Flood don't really heal so much as they repair themselves.
So, stubbers are basically useless against a proper Flood form, Pure or Combat, lasguns are pretty good, plasma is great, and the bane of the Flood's existence would be Necron gauss weaponry which tears things apart at the atomic level. Bolters would be decent since the impact of the shells themselves wouldn't do much damage, but the follow-up explosion would probably hurt like hell.
I don't think I know of an actual virus or similar alien existential threat in fiction that is more terrifying/powerful than the Flood.
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