I'll use the 'A Certain Magical/Scientific Index/Railgun/Accelerator" series as an example of this, but it's not limited just to them.
Researches and mages and scientists and whatever who's goal is to make/summon/whatever the 'ultimate X'. Aaaand? What do you get for this? People in Science City certainly spend a lot of time trying to make a Level 6 Psychic, and put a lot of resources to the task, often sacrificing a fair amount, but it constantly remains unclear what they get from this, since they almost assuredly don't have a means of control once they do. And it's not limited to level 6 psychics, but it's a thing.
Similarly people trying to summon gods and similar in different fictions, or sometimes genetically engineer 'the ultimate being'. It's like you really want to say them, 'your research is plenty impressive, but you do know once it's done your ultimate creation is just going to probably kill you, either on purpose or just as a side-effect of people trying to stop it, right?'.