Age of Empires also work for ONE very GOOD reason ->
Priest unit. It literally allows to with a bit of time to take over enemy units. All those Grimm? They may work for you instead
I just totally had a mental flash of a bible class crammed with different Grim, stuffed in sailor fuku's and listening to a priest teach theology.
As for what setting to draw in? Skyrim, hands down. The reason why is simple really, the MC needs personal arms and armour, as well as further fortifications to his camp and sufficient knowledge of agriculture to create a sustainable food source.
Skyrim should allow the MC access to Dwemer artifice. It should also allow the MC to combine said Dwemer artifice with enchanting, something the Dwemer never did directly due to them pursuing artifice over magic.
This in turn should allow for things such as a Van Helsing-style repeating crossbow that's strong enough to one-shot common grim such as Beowolves, or enchanted power armour.
More to the point, it'd allow the MC to build automations to reinforce his defensive perimeter and tend to a food garden, which it'd also give him the ability to successfully make.
And beyond everything else, it should give him the ability to develop a (possibly primitive) briarheart analogue or other easily created and enduring power source via enchanting, eliminating his dependence on his dwindling supplies of Dust.
An example of the minimum bar he should be able to surpass would be kludging together a primitive wind-powered generator and enhance it with magic, because again, Dwemer x Enchanting for the win.
All this aside though, chances are he'll need to forage the surrounding wilderness to supplement whatever un-rotted seed stock he finds in town in order to start a garden plot. In such circumstances, the ability to tell if something's poisonous either before or upon first taste is invaluable, and even more so for the ability to brew potions to cure or survive such poisoning, not to mention all the other uses being able to heal or otherwise enhance yourself has while surrounded by grim.
It's a hell of a lot better than command and conquer anyway:
"Oh hey, there's grim in the Forrest, let's build a base"
....
"Oh hey, grim are swarming the area, they must have been attracted by the building of my base..."
........
"Oh hey, grim are attacking and have somehow broken into my base. If only I had good enough arms and armour to fight them off with, or somehow realised this could happen." (studiously ignores the villagers who died attempting the exact same tactic...)
-
So yeah, command and conquer? Not a fan of picking it atm, maybe in another couple weeks when the MC has something approaching a decent basis for employing it's tech. As is, I don't really see him surviving the attempt to build the base in the first place, much less living long enough to get swarmed within it.
Fallout would be a decent pick due to it's aptitude for scavenging and making use of various forms of xenotech, which RWBY tech would fall under, but Skyrim would still be best between the two of them for now, because food.