I don't think they'd be completely outclassed. Now, they'd clearly not be far and away all-but-invincible, but they're not chumps. It would depend on whether Eden survived or not. She's supposed to be something of a planner, so she could probably scheme in such a way that didn't instantly turn everyone against them. Such a plan would likely involve handing out shards and trying to set up a situation where 'mere mortals' (with superpowers) managed to push back the darkness, challenge the various supernatural beings, and otherwise weaken them.
Hunters declaring that they're "Taking back the night" with laser vision, not knowing that all the while they were part of a slow plan to try to weaken everyone enough to allow the Entities to kill them all.
Would it succeed? Who knows, but I think that would be one of the plot points of some sort of 'Super: The Heroing" based on Worm, set in the nWoD.