The thing is drones tend to lack mobility, dexterity, skills and reaction times of humans making soldiers better than drones at certain things while drones allows one to drown the enemy in numbers with both having advantages hence why it makes sense to use both.
Mobility: Huh? Repulsors mean they are literally the most agile and mobile thing on the battlefield.
Dexterity: Context please.
Skills: Again context, remember we're talking about combat here, please because I'm not sure how any skills drones don't already possess come into play in shooting people.
Reaction Time: Are you joking? Computers react in milliseconds while humans react in seconds. This is literally the category in which Drones are the undeniable winders.
I seem to remember Hoyd mentioning something about Blackboxing drones being impractical. There also the fact that heavily relying on drones is a bad idea considering the fact that Blackboxing won't stop the Reapers from hacking PI tech.
To the best of my knowledge @Hoyr has never said anything about something being impractical to blackbox. The hacking problem is solved by not having hackable communications. QECs will easily provide enough communications bandwidth to send orders to fully autonomous drones.