Yes. Yes, I do.
Orochimaru's 3 defining traits are: he's obsessed with becoming Immortal, he's obsessed with learning all the Jutsu in the world, and he's an amoral mad scientist.
He knows that he doesn't know everything — that's why he experiments to learn new things. If he hears new information or a theory that contradicts something he has learned, his instinct will be to test it. Now, if he had tried killing a Tailed Beast personally, and come to the conclusion that it was impossible himself, then he might be more prone to dismiss it based on ego — but he knows that some things he read or learned about are wrong, because he's disproved them himself. He can accept that information he learned from other people is wrong, if only because his ego demands that they be considered lesser than him, and thus not infallible.