So I was going in hard with the vampires mod and realized that this playstyle is perfect for speedrunning and bypassing infrastructure roadblocks. They don't need food except for having animals around to feed on, they don't need to worry about temperature, they don't need medical care but they can use it, they're surprisingly stable and easy to maintain mood for, and they absolute dominate most human threats so long as they aren't wildly outnumbered.
The only real drawbacks is sunlight (but they can last to a certain extent and hang out under cover no problem), and how being attacked during the day can put you in a messy spot. They also can only travel during the night, but that's offset by them not needing any supplies. They're also not friendly to a rancher playstyle because they will kill your animals, there's no way to designate them as not-prey. Also, a vampire going out to hunt for blood will prioritize that over anything else, always. And if they pick a fight with a strong animal they can end up derailing a night of labor.
Bloodlines that use Domination disciplines (Lasombra, Tremere) are super useful since the first level spell can just Thanos snap mental states.
EDIT: Also since vampires are likely to kill animals feeding on them (even on the non-lethal feeding setting) it's viable to not assign a hunter but designate every animal as huntable. So their corpses will be automatically dragged to storage if they die. They're not that reliable in killing things, so maybe you assign someone to hunt situationally.
