Maybe, but my nWoD settings don't recognize the newer stuff from Onyx Path. You're not gonna find anything from Demon: The Descent, Beast: The Primordial, or Deviant in my Gotham. Even the Strix have been given the axe.
I disagree. New World of Darkness is explicitly designed as a toolkit, unlike the Classic World of Darkness (and to a lesser extent, the Chronicles of Darkness stuff from 2E) and Personal Horror isn't meant to be a "One True Way" but rather a default example to use as a potential reference
I always liked the challenge of "flipping the script" and making New World of Darkness into a "Supers With Fangs" setting via Rule Zero, both because I prefer that style and admittedly because I also like to spite the more toxic purist elements in the White Wolf fandom.
Tbh if you're doing a more kitchen sink style (and I 100% get the appeal of that from a creative writing/ST standpoint, the Changeling chronicle I ran had other supernatural splats around in supporting roles to sorta give the setting a feeling of...being inhabited? Fleshed out might be the term maybe. And also just 'cause I dig that kinda thing. Ultimately it worked out pretty well since the crux of the conflict was Changeling-centric and I'm probably going to do something similar for the Geist-game I'm prepping for, although I'd rather peel out one of my own fingernails with a pair of pliers than try to run mixed
parties), I'd strongly recommend at least taking a look at Geist 2e (which is such a 180 from first edition that it should genuinely be considered it's own thing and it's absolutely
fantastic, seriously I love it to bits) and giving Deviant a shot. A lot of the preliminary stuff that's been shown emphasizes how the Deviant is made, used, and abused by the inhumane (and sometimes inhuman) conspiracies that hunt them. Slotting that in with the existing spread of secret lodges and occult socities is pretty piss-easy and almost even a natural path if you're so inclined, and in general the concept of "lab experiment gone wrong"/"person hurt by their superhuman abilities" is pretty textbook comic stuff.
(Demon is cool conceptually but doesn't play well with other stuff and attempts to crowbar the God-Machine into other gamelines has gone...badly imo. Beast can just fuck off really.)
Honestly, as a tangent, if you're interested in a more overtly optimistic game I'd strongly suggest (again) checking out Geist 2e. It's got plenty of horror stuff obv (nWoD is fundamentally horror, there's not like- not much way of getting around that unless you're taking a bonesaw) but in general it's a game about Things Getting Better, activism and revolution, empathy and second chances. And is a more natural fit for that kinda positive take than Vampire. Like vampires as a whole can be all kinds of things, but Requiem's vampires very distinctly and deliberately sit at the intersection between, like, sex, death, and violence. You take. You hurt. Your Beast would drain the whole world dry if it had a chance and you'd maybe feel kinda bad that you don't feel worse about it. It makes Vampires great cinema-mobster analogues and Walter Whites and even supervillains yeah, but it makes them a really weird fit for heroes.
Sin-Eaters and their Geists literally have How Do You Help People as their guiding ethos, their krewes include the living, the dead, and can easily be modified to include the supernatural, and you don't have to cut out a party-hardy-murderfuck-mankind drive out of them to make them anything other than kinda monstrous.