Chakra Lemon Grenades? Quick! Don't let Cave Johnson near this world at all costs!
I mean, take a moment to think about it.
Cave Johnson's "throw stuff at the wall, and see what stick" brand of science seems to be Orochimaru's Modus Operandi…
"Mokuton! So, we took a few bits of the Shodai's corpse, we mashed 'em up real good, then we injected them into babies. With any luck, some of them will start showing super tree powers any day now!"
"So, it turns out that injecting 10-year-old corpses into babies is a really bad idea. Lesson learned, on to the next thing. Rumour has it, there's a clan nearby who can turn into smoke. Perfect for infiltrating unobserved, really bad for windy weather. Let's see if slapping on a Curse Seal can stabilise that bloodline."
"Good News: the Curse Seal can stabilise bloodlines. Bad News: Sarutobi-Sensei found out about my experiments. Been kicked out of the village, and he stuck a kill order on my head too. Bah! Who needs them — I'll just make my own village, for Science! Anyway, I've got some promising research into White Snakes and Immortality, so I guess that's the next project."