Okay, I see a lot of people saying things, and I'd like to make a few clarifications.
A) There are no longer "I become invincible to anything that isn't "Punch me in the face or talk at me, and punching you in the face always takes priority" effects in this Creation. You can become immune to the Wyld's ability to change your nature, and extend that protection to others--but you can't straight up no-sell eighty percent of the toolkit of anything that isn't another Exalt with a single, cheap Charm.
B) Just the same, there are excellent defenses against "I punch you into a duck" level effects, which can make it impossible for you to be instantly cursed into oblivion, by forcing the curse to allow an achievable "Break Condition", so even a death curse can be cured before it runs it's course. This allows for a greater variety of magic in the setting, because it's no longer a sucker bet, and it makes more twisty figures threatening again.
C) The Great Curse no longer keys off of Virtues (As those are no longer mechanically represented in the system), it keys off of intimacies, and there is no longer a single Break Condition, the ST picks one from a list based on the circumstances where the Break happens.
Interlude will be generated sometime today, no ETA yet.