Africa itself had deadly diseases in its jungles, and the Southern Tip was extremely remote and Dutch property. Now, its possible that the Dutch could have done more with the land and region, since it wasn't nearly so awful as the middle of Africa. But most trade involved the purchase and shipments of slaves and gold from the Gold Coast empires, mostly POWs, prisoners, and eventually random tribes rounded up for export. The diseases of Africa prevented deeper penetration of Central Africa outright, and Southern Africa was extremely remote and while it could have received extra attention early on from the moment the Dutch built the outposts, it just didn't, because North America was closer. Now if for some reason the Dutch start selling parts of that land to whoever can take it and defend it and general provide a decent atmosphere for colonization and do so early, they might attract people who are arriving specifically to be as far away from Europe as possible for whatever reason.
But it would have to start early and change both the behavior of the Dutch East India Company and that of the Netherlands itself.
You
can't colonise a non-post apocalyptic America if the natives don't let you, though; 16th century Europe has essentially no ability to project power over that sort of distance. The most similar model you'd be looking at there is the Portugese Empire in India, which was, funnily enough, fairly similar to early European 'colonisation' of Africa; a small number of coastal enclaves and then some Indian client states and trading partners. The Portugese simply couldn't ship enough men overseas to accomplish more.
This is because armies of the period needed a population base to support them in their area of operations. There's no real ability to set up regular shipments of supplies - early colonies often went years without seeing more ships, to the point where more colonists turned up and the colony was just gone, leaving everybody wondering just what the fuck happened. You can't just plonk a tercio down in Mexico and call it a day.
It's not a game of Europa Universalis, in other words. The historical European colonisation of the Americas relied on the continents having been depopulated before they got there in significant numbers. If that hasn't happened, then colonisation is going to be later, slower and more superficial; you'll have to wait until you can deploy and sustain significant armies over the Atlantic and outright
conquer the natives, in other words, rather than colonising empty land and pushing over countries already teetering on the edge of collapse and civil turmoil as a result of pandemic disease outbreaks.
The Spanish conquest of Mesoamerica was done on a shoestring with 'armies' of a couple of hundred men at the most, and only succeeded because the native countries were in the process of collapsing all on their own anyway,
and they could find native allies to help who were conveniently dying off as well, and therefore wouldn't be staying around to contest things afterwards. If you posit a situation where there are no pandemics, what'll happen is that Tlaxcala will help Cortez kick over the Aztecs, and maybe win (the Aztecs will be stronger here, remember), and then turn round and tell Cortez to fuck off when he tries to claim the land for Spain. There won't be anything he can do about it, because he's got a couple of hundred guys and no prospect of reinforcement, and the natives have tens of thousands.