Ah I see, well that explains the complete disconnect.
At no point did I actually intend to follow a comet to another star system, that's to slow. Comets in the interstellar medium tend to move at around 40 km/s and tend to take tens of thousands of years to get near other stars. Comets were as such at most seen as a potential point where one could recover some materials and perhaps do some repairs, if one just had to resupply resources. There comets contain a lot of water, they'd have sufficient hydrogen to replenish the fuel you'd be forced to expend on doing such a thing.
Still, that's at most extending your range a bit, or giving you slightly more options in case of problems, at the cost of travel time. Far from an ideal course of action.
From pretty much the start my thoughts were as such more on the far larger objects, the large Oort Clouds dwarf planets, and the soon afterwards introduced rogue planets in interstellar space. Why? Because you can just set up a permanent colony there.
It's not a way to reach another star, but the actual goal itself. A place that can be made in to a permanent point of living, a new nation. Planets should have a pretty good chance to have all the resources one needs to sustain populations of tens of millions, for millions of years. Thus making this basically a civilization in the dark.
Of course if such a civilization eventually built up enough over the centuries, they could then send out a colony to neighboring rogue planets and colonize those as well.
In doing such you'd have a very slow moving colonization wave, one that would eventually get around the entire galaxy hopping from rogue planet to rogue planet... or well if a stars just happens to be nearby one could go there as well.
Thus the advantage of this method is that you now no longer need to cross the gulf between stars, but can instead work with the much smaller gulf between planets. Dropping you from multiple light years of distance to cross, to just a few tenths of a light year. It's obvious that in the latter case your logistics for colonization would be greatly simplified.
And that's why I was wondering, there's still a lot of wondering to be done.
Running an organic factory is also going to be expensive, because you'll then need to keep your bacteria alive while they work and make sure there aren't already lots of impurities to poison them dead. Then you'll need to actually work the provided material and that can't bypass the industry requirement
Further research is most certainly wise, yes. Just like surveying anywhere you want to go to, is probably wise as well. You can always cancel the entire idea if that particular planet is no good.
And the organic system was just a proposal to try and get something more efficient then plasma arcing everything. Such a brutal system probably can survive deep space travel for long periods of time so it the fallback option is nothing better can be thought of.