Back on topic. Mass effect is bad. We get it.
I mean the topic is basically trying to mash up two entirely different things and doesn't even consider how this mashup works. The Terminator movies, fundamentally, are
horror movies that have sci-fi aesthetics.
Skynet is Satan, the cursed summer camp, the metaphor for humanity's sins that causes the slasher to appear. Skynet exists not to be some extremely well-defined villainous force, but a metaphor. The slasher is the Terminator-a human-seeming, but uncanny being with supernatural powers (superhuman strength, durability, the ability to hunt perfectly in the dark, surprising speed and resourcefulness) that has many of the aesthetics of the living dead. And Sarah Connor or John Connor are the troubled, but resourceful and intelligent, victims of the slasher. Both of them are the Final Girl, in a very real sense.
It's not really a good fit for a space opera because frankly Skynet's abilities, such that they are, are basically irrelevant. They're window dressing for why the slasher has its supernatural powers. Skynet is rarely an important character, and its motivations and actions are always made deliberately opaque. Why does Skynet want to kill humans? What's its reasoning, in-universe? You don't know, because it's not relevant. What
is relevant is that Skynet is a metaphor for our own willingness to implement destructive tools long before we consider the human consequences of doing so-like most of the things that empower slashers in horror movies, Skynet is a real-life human sin. Skynet is Facebook abetting the Rohingya genocide. Skynet is the surveillance state reading your emails to friends and lovers. Skynet is Google turning you into a product that's for sale.
You can make this mashup sort of work but that would be in the context of an actual story rather than just a random 'what-if.'