The Web-Warriors was a band of spider people dedicated to protecting the Web of Life and Destiny, and helping alternate universes without a spider. After two wars they barely survived, one of their members — Gwen Stacy aka Ghost-Spider of Earth-65 — tried to focus on repairing her civilian life back home.

Now, the universe of Earth Bet has been revealed, and she's asked to find the reason why it was hidden until now, and to find the elusive spider person that lives there. Gwen isn't doing it alone. When new spider people join the Warriors, she'll take under her wing another, younger Gwen. And their relationship will be more important to each other than they understand.