Gone are the years where Mutations were seen as dangerous omens of Humanity's end. Now they are 'Quirks' and the world has evolved around them until they became the norm. May Parker, the daughter of American Pro Hero Spider-Man, tries to follow the example set by his father and her childhood Hero, the legendary All Might, and to do so, she must study at U.A!

Unfortunately, she is not the only one in that path, and she would soon find herself entangled with the story of a familiar, green-haired...Girl?