The idea of fantasy world meets urban settings has been done and done well. It's called American Dragon: Jake Long.
You think I kid but I'm not. American Dragon was fucking great. It mixes the supernatural with traditional Chinese myths and the hardships of urban living. It's not the most deep example nor the most serious one but it achieves the goal of telling the hardships of a half-white/Chinese teen in New York while balancing the stress of being a student. You can see the same thing with Danny Phantom but replace the fantasy with ghosts.
It also launched the voice acting of Dante Brasco and the world is better for his talent.
Let's use another hypothetical example: Muslim characters and Islamic theology plus mythos in sci-fi and fantasy. Just because there's a lack of it doesn't mean it can't be done well either.